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Registro Completo |
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Biblioteca(s): |
Embrapa Café; Embrapa Mandioca e Fruticultura. |
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Data corrente: |
21/01/2022 |
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Data da última atualização: |
05/12/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
TORRES, L. G.; OLIVEIRA, E. J. de; OGBONNA, A. C.; BAUCHET, G. J.; MUELLER, L. A.; AZEVEDO, C. F.; SILVA, F. F.; SIMIQUELI, G. F.; RESENDE, M. D. V. de. |
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Afiliação: |
LÍVIA GOMES TORRES, UFV; EDER JORGE DE OLIVEIRA, CNPMF; ALEX C. OGBONNA, CORNELL UNIVERSITY; GUILLAUME J. BAUCHET, BOYCE THOMPSON INSTITUTE; LUKAS A. MUELLER, CORNELL UNIVERSITY; CAMILA FERREIRA AZEVEDO, UFV; FABYANO FONSECA E SILVA, UFV; GUILHERME FERREIRA SIMIQUELI, UFV; MARCOS DEON VILELA DE RESENDE, CNPCa. |
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Título: |
Can cross-country genomic predictions be a reasonable strategy to support germplasm exchange? A case study with hydrogen cyanide in cassava. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Frontiers in Plant Science, v. 12, 742638, 2021. |
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ISSN: |
1664-462X |
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DOI: |
https://doi.org/10.3389/fpls.2021.742638 |
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Idioma: |
Inglês |
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Conteúdo: |
Genomic prediction (GP) offers great opportunities for accelerated genetic gains by optimizing the breeding pipeline. One of the key factors to be considered is how the training populations (TP) are composed in terms of genetic improvement, kinship/origin, and their impacts on GP. Hydrogen cyanide content (HCN) is a determinant trait to guide cassava?s products usage and processing. This work aimed to achieve the following objectives: (i) evaluate the feasibility of using cross-country (CC) GP between germplasm?s of Embrapa Mandioca e Fruticultura (Embrapa, Brazil) and The International Institute of Tropical Agriculture (IITA, Nigeria) for HCN; (ii) provide an assessment of population structure for the joint dataset; (iii) estimate the genetic parameters based on single nucleotide polymorphisms (SNPs) and a haplotype-approach. Datasets of HCN from Embrapa and IITA breeding programs were analyzed, separately and jointly, with 1,230, 590, and 1,820 clones, respectively. After quality control, ~14K SNPs were used for GP. The genomic estimated breeding values (GEBVs) were predicted based on SNP effects from analyses with TP composed of the following: (i) Embrapa genotypic and phenotypic data, (ii) IITA genotypic and phenotypic data, and (iii) the joint datasets. Comparisons on GEBVs' estimation were made considering the hypothetical situation of not having the phenotypic characterization for a set of clones for a certain research institute/country and might need to use the markers? effects that were trained with data from other research institutes/country's germplasm to estimate their clones? GEBV. Fixation index (FST) among the genetic groups identified within the joint dataset ranged from 0.002 to 0.091. The joint dataset provided an improved accuracy (0.8-0.85) compared to the prediction accuracy of either germplasm?s sources individually (0.51-0.67). CC GP proved to have potential use under the present study's scenario, the correlation between GEBVs predicted with TP from Embrapa and IITA was 0.55 for Embrapa's germplasm, whereas for IITA?s it was 0.1. This seems to be among the first attempts to evaluate the CC GP in plants. As such, a lot of useful new information was provided on the subject, which can guide new research on this very important and emerging field. MenosGenomic prediction (GP) offers great opportunities for accelerated genetic gains by optimizing the breeding pipeline. One of the key factors to be considered is how the training populations (TP) are composed in terms of genetic improvement, kinship/origin, and their impacts on GP. Hydrogen cyanide content (HCN) is a determinant trait to guide cassava?s products usage and processing. This work aimed to achieve the following objectives: (i) evaluate the feasibility of using cross-country (CC) GP between germplasm?s of Embrapa Mandioca e Fruticultura (Embrapa, Brazil) and The International Institute of Tropical Agriculture (IITA, Nigeria) for HCN; (ii) provide an assessment of population structure for the joint dataset; (iii) estimate the genetic parameters based on single nucleotide polymorphisms (SNPs) and a haplotype-approach. Datasets of HCN from Embrapa and IITA breeding programs were analyzed, separately and jointly, with 1,230, 590, and 1,820 clones, respectively. After quality control, ~14K SNPs were used for GP. The genomic estimated breeding values (GEBVs) were predicted based on SNP effects from analyses with TP composed of the following: (i) Embrapa genotypic and phenotypic data, (ii) IITA genotypic and phenotypic data, and (iii) the joint datasets. Comparisons on GEBVs' estimation were made considering the hypothetical situation of not having the phenotypic characterization for a set of clones for a certain research institute/country and might need to use the marke... Mostrar Tudo |
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Thesagro: |
Cianeto; Genoma; Germoplasma; Mandioca. |
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Thesaurus Nal: |
Breeding; Cassava; Genomics; Hydrogen cyanide; Population structure. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1149230/1/Santos-et-al-ASA-2023.pdf
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/230436/1/can-cross-country.pdf
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Marc: |
LEADER 03330naa a2200349 a 4500
001 2149230
005 2022-12-05
008 2021 bl uuuu u00u1 u #d
022 $a1664-462X
024 7 $ahttps://doi.org/10.3389/fpls.2021.742638$2DOI
100 1 $aTORRES, L. G.
245 $aCan cross-country genomic predictions be a reasonable strategy to support germplasm exchange? A case study with hydrogen cyanide in cassava.$h[electronic resource]
260 $c2021
520 $aGenomic prediction (GP) offers great opportunities for accelerated genetic gains by optimizing the breeding pipeline. One of the key factors to be considered is how the training populations (TP) are composed in terms of genetic improvement, kinship/origin, and their impacts on GP. Hydrogen cyanide content (HCN) is a determinant trait to guide cassava?s products usage and processing. This work aimed to achieve the following objectives: (i) evaluate the feasibility of using cross-country (CC) GP between germplasm?s of Embrapa Mandioca e Fruticultura (Embrapa, Brazil) and The International Institute of Tropical Agriculture (IITA, Nigeria) for HCN; (ii) provide an assessment of population structure for the joint dataset; (iii) estimate the genetic parameters based on single nucleotide polymorphisms (SNPs) and a haplotype-approach. Datasets of HCN from Embrapa and IITA breeding programs were analyzed, separately and jointly, with 1,230, 590, and 1,820 clones, respectively. After quality control, ~14K SNPs were used for GP. The genomic estimated breeding values (GEBVs) were predicted based on SNP effects from analyses with TP composed of the following: (i) Embrapa genotypic and phenotypic data, (ii) IITA genotypic and phenotypic data, and (iii) the joint datasets. Comparisons on GEBVs' estimation were made considering the hypothetical situation of not having the phenotypic characterization for a set of clones for a certain research institute/country and might need to use the markers? effects that were trained with data from other research institutes/country's germplasm to estimate their clones? GEBV. Fixation index (FST) among the genetic groups identified within the joint dataset ranged from 0.002 to 0.091. The joint dataset provided an improved accuracy (0.8-0.85) compared to the prediction accuracy of either germplasm?s sources individually (0.51-0.67). CC GP proved to have potential use under the present study's scenario, the correlation between GEBVs predicted with TP from Embrapa and IITA was 0.55 for Embrapa's germplasm, whereas for IITA?s it was 0.1. This seems to be among the first attempts to evaluate the CC GP in plants. As such, a lot of useful new information was provided on the subject, which can guide new research on this very important and emerging field.
650 $aBreeding
650 $aCassava
650 $aGenomics
650 $aHydrogen cyanide
650 $aPopulation structure
650 $aCianeto
650 $aGenoma
650 $aGermoplasma
650 $aMandioca
700 1 $aOLIVEIRA, E. J. de
700 1 $aOGBONNA, A. C.
700 1 $aBAUCHET, G. J.
700 1 $aMUELLER, L. A.
700 1 $aAZEVEDO, C. F.
700 1 $aSILVA, F. F.
700 1 $aSIMIQUELI, G. F.
700 1 $aRESENDE, M. D. V. de
773 $tFrontiers in Plant Science$gv. 12, 742638, 2021.
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Registro original: |
Embrapa Mandioca e Fruticultura (CNPMF) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
03/11/2021 |
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Data da última atualização: |
03/11/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
TORRES, D. S.; OLIVEIRA, B. A. de; SILVEIRA, L. S. da; SILVA, M. P. da; PEREIRA; MORAES, J.; COURI, M. R. C.; QUEIROZ, R. F. G. e; PARREIRAS, P. M.; SILVA, M. R.; ALVES, L. A.; SOUZA, V. C. de; GOLIATT, P. V. Z. C.; VASCONCELOS, E. G.; SILVA FILHO, A. A. da; PINTO, P. de F. |
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Afiliação: |
DANIEL SILVA TORRES, Universidade Federal de Juiz de Fora; BRUNA ALVES DE OLIVEIRA, Universidade Federal de Juiz de Fora; LÍGIA SOUZA DA SILVEIRA, Universidade Federal de Juiz de Fora; MARCOS PAULO DA SILVA, Universidade de Guarulhos; VINÍCIUS RODRIGUES DURÃES PEREIRA, Universidade Federal de Juiz de Fora; JOSUÉ MORAES, Universidade de Guarulhos; MARA RÚBIA COSTA COURI, Universidade Federal de Juiz de Fora; RAFAELLA FORTINI GRENFELL E QUEIROZ, Fundação Oswaldo Cruz; PATRÍCIA MARTINS PARREIRAS, Fundação Oswaldo Cruz; MARCIO ROBERTO SILVA, CNPGL; LARA AZEVEDO ALVES, Universidade Federal de Juiz de Fora; VINÍCIUS CARIUS DE SOUZA, Universidade Federal de Juiz de Fora; PRISCILA VANESSA ZABALA CAPRILES GOLIATT, Universidade Federal de Juiz de Fora; EVELINE GOMES VASCONCELOS, Universidade Federal de Juiz de Fora; ADEMAR ALVES DA SILVA FILHO, Universidade Federal de Juiz de Fora; PRISCILA DE FARIA PINTO, Universidade Federal de Juiz de Fora. |
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Título: |
Synthetic aurones: new features for Schistosoma mansoni therapy. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Chemistry & Biodiversity, v. 18, e2100439, 2021. |
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DOI: |
https://doi.org/10.1002/cbdv.202100439 |
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Idioma: |
Inglês |
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Conteúdo: |
In this work, two synthetic aurones revealed moderate schistosomicidal potential in in vitro and in vivo assays. Aurones (1) and (2) promoted changes in tegument integrity and motor activity, leading to death of adult Schistosoma mansoni worms in in vitro assays. When administered orally (two doses of 50mg/kg) in experimentally infected animals, synthetic aurones (1) and (2) promoted reductions of 56.20% and 57.61% of the parasite load and stimulated the displacement towards the liver of the remaining adult worms. The oogram analysis revealed that the treatment with both aurones interferes with the egg development kinetics in the intestinal tissue. Seeking an action target for compounds (1) and (2), the connection with NTPDases enzymes, recognized as important therapeutic targets for S. mansoni, was evaluated. Molecular docking studies have shown promising results. The dataset reveals the anthelmintic character of these compounds, which can be used in the development of new therapies for schistosomiasis. |
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Palavras-Chave: |
Anthelmintic; Chistosoma mansoni; NTPDases; SmATPDase. |
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Thesagro: |
Esquistossomose; Flavonóide; Schistosoma Mansoni; Verminose. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02161naa a2200409 a 4500
001 2135763
005 2021-11-03
008 2021 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1002/cbdv.202100439$2DOI
100 1 $aTORRES, D. S.
245 $aSynthetic aurones$bnew features for Schistosoma mansoni therapy.$h[electronic resource]
260 $c2021
520 $aIn this work, two synthetic aurones revealed moderate schistosomicidal potential in in vitro and in vivo assays. Aurones (1) and (2) promoted changes in tegument integrity and motor activity, leading to death of adult Schistosoma mansoni worms in in vitro assays. When administered orally (two doses of 50mg/kg) in experimentally infected animals, synthetic aurones (1) and (2) promoted reductions of 56.20% and 57.61% of the parasite load and stimulated the displacement towards the liver of the remaining adult worms. The oogram analysis revealed that the treatment with both aurones interferes with the egg development kinetics in the intestinal tissue. Seeking an action target for compounds (1) and (2), the connection with NTPDases enzymes, recognized as important therapeutic targets for S. mansoni, was evaluated. Molecular docking studies have shown promising results. The dataset reveals the anthelmintic character of these compounds, which can be used in the development of new therapies for schistosomiasis.
650 $aEsquistossomose
650 $aFlavonóide
650 $aSchistosoma Mansoni
650 $aVerminose
653 $aAnthelmintic
653 $aChistosoma mansoni
653 $aNTPDases
653 $aSmATPDase
700 1 $aOLIVEIRA, B. A. de
700 1 $aSILVEIRA, L. S. da
700 1 $aSILVA, M. P. da
700 1 $aPEREIRA
700 1 $aMORAES, J.
700 1 $aCOURI, M. R. C.
700 1 $aQUEIROZ, R. F. G. e
700 1 $aPARREIRAS, P. M.
700 1 $aSILVA, M. R.
700 1 $aALVES, L. A.
700 1 $aSOUZA, V. C. de
700 1 $aGOLIATT, P. V. Z. C.
700 1 $aVASCONCELOS, E. G.
700 1 $aSILVA FILHO, A. A. da
700 1 $aPINTO, P. de F.
773 $tChemistry & Biodiversity$gv. 18, e2100439, 2021.
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Embrapa Gado de Leite (CNPGL) |
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